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Friday, 31 May 2013

New Drug from UTSW Could Offer Prostate Cancer Treatment

New Drug from UTSW Could Offer Prostate Cancer Treatment
D Healthcare Daily
Raj hopes the drug that has been tested in mouse and human tissue will lead to new treatment options and increased longevity for men diagnosed with prostate cancer. Additional testing is needed before the drug can be studied in Phase 1 clinical trials ...

 
http://healthcare.dmagazine.com/2013/05/29/new-drug-from-utsw-offers-possible-prostate-cancer-treatment/

GSK Hits Trifecta with Melanoma Drug, Dx Approvals

GSK Hits Trifecta with Melanoma Drug, Dx Approvals
Genetic Engineering News
A total 250 previously untreated adult patients with BRAF V600E mutation-positive unresectable or metastatic melanoma were randomized to either drug. Mekinist was approved after Phase III data showed a statistically significant increase in PFS, to a ...


http://www.genengnews.com/gen-news-highlights/gsk-hits-trifecta-with-melanoma-drug-dx-approvals/81248422/

Great News For Gilead Sciences And HCV Patients

Great News For Gilead Sciences And HCV PatientsSeeking AlphaGilead submitted a New Drug Application [NDA] with the same Phase 3 trial data to the FDA in April 2013. The FDA has since issued a Form 483 letter questioning the company's test procedures, stability testing and laboratory controls regarding several ...http://seekingalpha.com/article/1465861-great-news-for-gilead-sciences-and-hcv-patients?source=google_news

Pacira Pharmaceuticals, Inc. Announces Positive Interim Analysis of EXPAREL in Femoral Nerve Block f

Pacira Pharmaceuticals, Inc. Announces Positive Interim Analysis of EXPAREL ...DailyFinanceWe look forward to initiating the Phase 3 portion of this trial and ultimately to providing orthopedic patients with a new option that could significantly contribute to the management of their postsurgical pain by replacing a perineural catheter, drug ...http://www.dailyfinance.com/2013/05/29/pacira-pharmaceuticals-inc-announces-positive-inte/

Is This the Beginning of the End for Alzheimer's?

Is This the Beginning of the End for Alzheimer's?Motley FoolUnfortunately, no matter how promising drugs appear in phase 2 results, they fail in phase 3 trials without slowing the progression of this debilitating neurological disease. Now, researchers at the University of Cambridge have discovered the mechanism ...
http://www.fool.com/investing/general/2013/05/29/is-this-the-beginning-of-the-end-for-alzheimers.aspx

Monday, 27 May 2013

Structural Biology: Sulfonamide drugs may harm nervous systems by inhibiting an enzyme



This is a ribbon structure of an enzyme with sulfa drugs interacting with it.
 
Many sulfonamide drugs, such as sulfapyridine (pink), inhibit the enzyme sepiapterin reductase (blue), shown with a cofactor (green).
Credit: Science
Links
 

A new tumor-killer




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Scientists from Nanyang Technological University (NTU) and Lund University, Sweden, have bioengineered a novel molecule proven to successfully kill tumor cells. This molecule is based on a natural protein present in human breast milk, which has been found to have strong and wide-ranging tumor killing properties when bound to certain lipids. Lipids are organic molecules … more…

Radioactive nanoparticles selectively target cancer cells



the nanoparticles as designed by Lewis and Robertson. The green interior depicts the radioactive lutetium surrounded by a gold shell. Credit can go to Michael Lewis, University of Missouri and Harry S. Truman Memorial Veterans’ Hospital.







Researchers at the University of Missouri have found a way to create radioactive nanoparticles that target lymphoma tumor cells wherever they may be in the body. Michael Lewis, an associate professor of oncology in the MU College of Veterinary Medicine, says being able to target secondary tumors is vital to successfully treating patients with progressive … more…

Awakening to New Drugs against Sleeping Sickness

Awakening to New Drugs against Sleeping Sickness

Structure–activity relationships and optimization of triazine nitriles as rhodesain inhibitors
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New Route to Anticancer Agent Quinocarcin

 


Synthesis of quinocarcin through a convergent strategy based on Sonogashira coupling and gold(I)-catalyzed hydroamination
Read more

Hope for Hepatitis Drug

Hope for Hepatitis Drug


A straightforward synthesis of an antiviral drug, entecavir, to treat hepatitis B has industrial scale-up potential
Read more

Reducing caloric intake delays nerve cell loss



(Credit: iStockphoto)

Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May 22 issue of The Journal of Neuroscience. The findings could one day guide researchers to discover drug alternatives that slow … more…

Scientists sequence genome of ‘sacred lotus,’ may hold anti-aging secrets



Nelumbo nucifera from China, more commonly known as the 'sacred lotus'
(Credit: Jane Shen-Miller /UCLA)

A team of 70 scientists from the U.S., China, Australia and Japan reports having sequenced and annotated more than 86 percent of the genome of the “sacred lotus,” which is believed to have a powerful genetic system that repairs genetic defects, and may hold secrets about aging successfully. The Nelumbo nucifera plant is revered in … more…

Do salamanders hold the solution to regeneration


Do salamanders hold the solution to regeneration

401px-SpottedSalamander

Salamanders’ immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have found. In research published in the Proceedings of the National Academy of Sciences (open access), researchers from the Australian Regenerative Medicine Institute (ARMI) at … more…