A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

An immobilised monolithic iridium hydrogen transfer catalyst has been developed for use in flow based processing. The monolithic construc thas been used for several redox reductions demonstrating excellent recyclability, good turnover numbersand high chemical stability giving negligible metal leaching over extended periods of use.

A FlowSyn Auto-LF system was employed to automatically process a library of 40 aldehydes and ketones.

Maria Victoria Rojo,*a Lucie Guetzoyana and Ian. R. Baxendale Org. Biomol. Chem., 2015, 13, 1768

An immobilised iridium hydrogen transfer catalyst has been developed for use in flow based processing by incorporation of a ligand into a porous polymeric monolithic flow reactor. The monolithic construct has been used for several redox reductions demonstrating excellent recyclability, good turnover numbers and high chemical stability giving negligible metal leaching over extended periods of use.

Maria Victoria Rojo,*^a   Lucie Guetzoyan^a and  Ian. R. Baxendale^ab   

 

*Corresponding authors

^aDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: mavirm@hotmail.com

^bDepartment of Chemistry, University of Durham, South Road, Durham, UK

Org. Biomol. Chem., 2015,13, 1768-1777

DOI: 10.1039/C4OB02376E

http://pubs.rsc.org/en/content/articlelanding/2015/ob/c4ob02376e#!divAbstract

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