Showing posts with label Anticancer Agent. Show all posts
Showing posts with label Anticancer Agent. Show all posts

Tuesday 17 September 2013

Drug therapy: Solamargine and other solasodine rhamnosyl glycosides as anticancer agents





Modern ChemotherapyVol.2 No.2(2013), Article ID:30489,17 pagesDOI:10.4236/mc.2013.22005
Drug therapy: Solamargine and other solasodine rhamnosyl glycosides as anticancer agents
Bill E. Cham
Australasian Institute of Medical Research, Brisbane, Australia; bill.cham@gmail.com
Copyright © 2013 Bill E. Cham. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received 24 February 2013; revised 26 March 2013; accepted 5 April 2013
Keywords: Cancer; Skin Cancer; Solamargine; Solasonine; BEC; Solasodine Rhamnosyl Glycosides; CuradermBEC5; Apoptosis; Antineoplastic; Targeted Therapy
ABSTRACT
In the last century, the discovery of cytotoxic agents was revolutionary for anticancer therapy. These therapies have resulted in better understanding of cancer in general. However, the development of agents that combine efficacy, safety and convenience remains a great challenge. The narrow, if not adverse, therapeutic index of most drugs, the damage not only to cancer cells, but also to normal and healthy tissue and the occurrence of resistance have limited anticancer efficacy. This review presents the development of promising novel cytotoxic solasodine rhamnosyl glycoside drugs that offer not only gains in specificity and efficacy, but also in safety, tolerability, non-resistance and convenience in the treatment of patients with cancer.
1. INTRODUCTION
In the past 100 years our understanding of the biology of cancer has come a long way. We now have a reasonable working knowledge of how tumors initially form, grow and spread. Importantly, substantial information about features distinguishing tumor from normal cells is being accumulated, resulting in major new insights into cancer biology................
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Tuesday 30 July 2013

Garlic an antifungal, garlic can also support your immune system, reduce cholesterol, and help control blood sugar levels.

garlic

Garlic is a proven antifungal . Research studies have shown that garlic is effective against pathogens like Candida. In addition to its use as an antifungal, garlic can support your immune system, reduce cholesterol, and help control blood sugar levels.
You can start taking garlic supplements once you have finished your cleanse and moved on to the strict anti-Candida diet. As always, it is better to take two or three antifungals at once to prevent the Candida from adapting, so you can use garlic in addition to other natural antifungals.

How does Garlic help with Candida overgrowth?

There is a wide range of scientific literature supporting the use of garlic as an antifungal. Much of this research is focused on Candida and similar pathogenic organisms. For example, a 1988 study (see the full text here) found that “the growth of Candida Albicans was found to be markedly inhibited by AGE [aqueous garlic extract]”. According to another article by Huntington College of Health Sciences, “Research has clearly shown that garlic has anticandidal activity, inhibiting both the growth and function of Candida Albicans”.
One of the key compounds in garlic is ajoene, a proven antifungal that has been shown to be effective against many fungal strains. Ajoene is formed from a compound named allicin and an enzyme named allinase. When these two natural compounds come into contact (by chopping the garlic, crushing it or by other means), they form an antibacterial agent named allicin, which then combines to form ajoene. Although this has proven antifungal properties, the exact mechanism by which this happens is not clear. As with other antifungals, scientists suspect that it works by disrupting the cells walls of the Candida yeast cells.
A major advantage of garlic is that it is so easy to include in your treatment plan. Garlic tablets, softgels and oils are widely available, and fresh garlic cloves make a tasty addition to many recipes. You can use garlic as a complement to your other antifungals without having to spend a great deal of money. To get the best results and prevent the Candida yeast from adapting to the treatment, it is best to take two or three antifungals at the same time.

How do you take Garlic?

Garlic products can be found in a number of different forms, in both your supermarket and your health food store. In your supermarket you will find items like fresh garlic cloves, garlic paste, crushed garlic, garlic flakes or garlic powder. Your health food store should stock garlic tablets and garlic oil.
Each type contains different levels of the active ingredients, so make sure to read the ingredients. Here is a basic run-down of the recommended dosage for each type:
  • Garlic cloves: 2 to 4 grams per day of fresh, minced garlic clove
  • Garlic Tablets: 600 to 900 mg daily, freeze-dried garlic standardized to 1.3% alliin or 0.6% allicin
  • Garlic Oil: 0.03 to 0.12 mL three times a day

Who should not take Garlic?

Although a natural remedy, concentrated garlic can still interact with other medicines, so always consult a health professional. Garlic has a blood-thinning property that can be very useful, but can also be dangerous to sufferers of hemophilia or platelet disorders, as well as pregnant women or patients about to undergo surgery.
Side effects from garlic include upset stomach, bloating, bad breath, body odor, and a stinging sensation on the skin from handling too much fresh or dried garlic. Handling garlic may also cause the appearance of skin lesions.
Other side effects that have been reported by those taking garlic supplements include headache, fatigue, loss of appetite, muscle aches, dizziness described as vertigo (namely, the room spinning), and allergies such as an asthmatic reaction or contact dermatitis (skin rash).
Some people may suffer a mild allergic reaction to concentrated garlic. Others may have an upset stomach, body odor, bad breath, headache, loss of appetite or fatigue. It may prompt a skin reaction, such as a stinging in the hands.

Friday 26 July 2013

5 Must To Have Foods To Keep The Levels Of High Cholesterol Under Control

Picture
A condition called high cholesterol slowly creeps on you and you are unable to see its ill-effects until it becomes unbearable with spike to several complications such as diabetes, heart diseases and much more.

Other than just to pop up pills to keep the level of bad cholesterol or LDL under check, it is always a good choice to go for 5 must to have foods to keep the levels of high cholesterol under control. Thus, let’s go straight and see them.
  1. Oats- Oats are believed to have soluble fiber whose intake can easily lower the cholesterol level. Adding oatmeal every day at breakfast can lower your high cholesterol level.
  2. Beans- Similarly like oats beans are also especially rich in soluble fiber that can easily help your cholesterol level to keep low. Beans can also help to lose weight and makes one feel fuller as they take longer to digest.
  3. Nuts- Several studies all across have shown that nuts are a superb food choice when dealing with high cholesterol level as it can significantly lower your high LDL levels. What’s more, it is also a great option to keep your heart healthy.
  4. Stereos and Stalons rich foods- Foods rich in sterols and stallions can lower the cholesterol as they have the power to absorb cholesterol from foods. Always check food labels to see if they contain these substances.
  5. Fatty Fish- Are you a fish fan? If so, you are lucky as fish such as Salmon and Tuna possess Omega 3 fatty acids that can lower down the level of cholesterol. It would cut your intake of meat as it can increase cholesterol level and instead go for fish.
http://globalmedscanadadrugs.weebly.com/1/post/2013/07/5-must-to-have-foods-to-keep-the-levels-of-high-cholesterol-under-control.html
video on cholesterol reduction one more

Tuesday 23 July 2013

Phase III prostate cancer trial for 'homing' injection shows improvements


Prostate cancer

Phase III prostate cancer trial for 'homing' injection shows improvements
A new treatment for advanced prostate cancer that homes-in on tumours to deliver a high-energy burst of radiation to cancer cells has shown significant benefits in a large scale clinical trial.
The trial of 921 patients showed that treatment with the radioactive Radium-223 gave men with late-stage prostate cancer an average extra of 15 weeks of life.http://www.pharmaceutical-technology.com/news/newsphase-iii-prostate-cancer-trial-for-homing-injection-shows-benefit?WT.mc_id=DN_News

Monday 22 July 2013

Anticancer agent – elacytarabin

Elacytarabine
Cytarabine is a cytosine derivative that is a common component of chemotherapy regimens for blood cancers such as acute myeloid leukaemia (AML), and because it can cross the blood–brain barrier, it is useful in the treatment of central nervous system lymphomas. However, the response is variable, and resistance commonly develops via multiple mechanisms. Its activity is dependent on the intracellular concentrations of the active phosphorylated form, and one of the main mechanisms of resistance involves the deficiency of the transporter molecule hENT1 that carries it into the cells. As a result, Clavis Pharma developed a lipophilic ester derivative, elacytarabine, whose cellular uptake is not hENT1-dependent.1
- See more at:http://www.manufacturingchemist.com/technical/article_page/Anticancer_agent__elacytarabine/83035

 http://www.manufacturingchemist.com/technical/article_page/Anticancer_agent__elacytarabine/83035#sthash.bF8Vqa3M.dpuf

Monday 8 July 2013

University of East Anglia scientists make major advance important for cancer research

Above: EB2 (green) expressed in stem cell region of gut with microtubules in red (credit: Deborah Goldspink) 

University of East Anglia scientists make major advance important for cancer research

Dr Mette Mogensen’s lab from UEA's School of Biological Sciences has made a major advancement in understanding tissue development that has important implications for cancer. Findings published today in the Journal of Cell Science show how the protein EB2 is a key regulator of tube-like...

Thursday 20 June 2013

Saturday 8 June 2013

Eculizumab proves effective in treating atypical hemolytic uremic syndrome

ECULIZUMAB


A new treatment for patients with atypical hemolytic uremic syndrome ( aHUS) was tested by researchers at Emory University. According to an article published in the New England Journal of Medicine, it seems that eculizumab, a monoclonal antibody, is effective in the management of this life-threatening inflammatory disease.
 
Hemolytic uremic syndrome, which is a thrombotic microangiopathy that causes blood clots in small vessels, is characterized by thrombocytopenia, hemolytic anemia and uremia. It mostly affects children up to 7 years old and is the most common cause of acute renal failure in children. The hemolytic uremic syndrome is often associated with enteric infections (E. coli, Shigella, Salmonella, etc.), but it can occur in other situations such as after certain drugs, tumors, after transplantation, etc..

Read more: http://www.doctortipster.com/14800-eculizumab-proves-effective-in-treating-atypical-hemolytic-uremic-syndrome.html






Site of action of eculizumab. a Complement C5 is split by C5 convertase into C5a and C5b. C5a increases the permeability of blood vessels and attracts inflammatory cells by chemotaxis. C5b binds to other complement components (C6, C7, and C8). The C5b-8 complex is expanded with C9 to form the MAC. MAC binds and permeabilizes bacterial walls (e.g. Neisseria), thereby killing the microorganism. b Eculizumab is a long-acting humanized monoclonal antibody targeted against complement C5. It inhibits the cleavage of C5 into C5a and C5b and hence inhibits deployment of the terminal complement system including the formation of MAC








Site of action of eculizumab. a Complement C5 is split by C5 convertase into C5a and C5b. C5a increases the permeability of blood vessels and attracts inflammatory cells by chemotaxis. C5b binds to other complement components (C6, C7, and C8). The C5b-8 complex is expanded with C9 to form the MAC. MAC binds and permeabilizes bacterial walls (e.g. Neisseria), thereby killing the microorganism. b Eculizumab is a long-acting humanized monoclonal antibody targeted against complement C5. It inhibits the cleavage of C5 into C5a and C5b and hence inhibits deployment of the terminal complement system including the formation of MAC
 

Friday 24 May 2013