Sunday, 4 August 2013

Medicinal Herbs Show Ability to Replace Diabetes Medication without Side Effects

Medicinal Herbs Show Ability to Replace Diabetes Medication without Side Effects
Researchers from University of Mississippi's School of Pharmacy have conducted an extensive analysis of medicinal plants and proved once again that herbs can replace medications - now diabetes medications. They found that a number of herbs safely modulate cellular PPAR receptors – which means they help regulate glucose, insulin and fat metabolism.
The researchers screened extracts from a total of 263 species of herbs from 94 plant families. They found that eight of the extracts activated the PPARα (Peroxisome proliferator-activated receptor – alpha) and 22 of the plant extracts activated the PPARγ (Peroxisome proliferator-activated receptor – gamma).
Of these, five plant extracts activated both receptors. They were Daphine (Daphne gnidium), Star Anise (Illicium anisatum), Red Cedar (Juniperus virginiana), Haritaki (Terminalia chebula), and Thymelaea (Thymelaea hirsuta).
http://www.greenmedinfo.com/blog/medicinal-herbs-show-ability-replace-diabetes-medication-without-side-effects

Saturday, 3 August 2013

MICROENCAPSULATION: ADVANCEMENTS IN TECHNOLOGY AND ITS PATENTS



Microcapsule is a tiny sphere including core material/internal phase or fill, coated with/surrounded by wall know as shell, coating or membrane. The usual size range of the microcapsule lies between 1 to 1000 μm. The technique is usually applied for targeted drug delivery, protection of the molecule and stability if the core material. Microencapsulation system offers potential advantages over conventional drug delivery systems and also established as unique carrier systems for many pharmaceuticals. This article contains the traditional and the recent techniques, including their patents, for the preparation of microcapsules. Solvent exchange method, coacervation, polymerization, hot melts etc are several recent techniques are used for the preparation of the microcapsules. The microencapsulation technique, as Novel drug Delivery System (NDDS), is widely applied for delivery of probiotics, drugs, pesticide, food etc. Although significant advances have been made in the field of microencapsulation, still many challenges need to be rectified during the appropriate selection of core materials, coating materials and process techniques.... read all at
http://www.pharmatutor.org/articles/microencapsulation-advancements-technology-patents

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Thursday, 1 August 2013

Alexza Pharmaceuticals Announces European Launch of ADASUVE® (Staccato® Loxapine)



LOXAPINE

MOUNTAIN VIEW, Calif., July 30, 2013 /PRNewswire/ -- Alexza Pharmaceuticals, Inc. (ALXA) today announced that the company's commercial partner Grupo Ferrer Internacional, S.A. has initiated sales of ADASUVE® inhalation powder, pre-dispensed (Staccato® Loxapine) in the European Union ("EU").  ADASUVE is now available in Germany.  The first sale and shipment of product by Ferrer triggers a $1.25 million milestone payment to Alexza, pursuant to the Company's collaboration agreement with Ferrer.

http://finance.yahoo.com/news/alexza-pharmaceuticals-announces-european-launch-130000571.html


Loxapine (LoxapacLoxitane) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. It is a member of the dibenzoxazepine class and structurally related to clozapine (which belongs to the chemically akin class ofdibenzodiazepines). Several researchers have argued that Loxapine may behave as an atypical antipsychotic.
Loxapine may be metabolized by N-demethylation to amoxapine, a tetracyclic antidepressant





Schmutz, J.; Kunzle, F.; Hunziker, F.; Gauch, R.; Helv. Chim. Acta 1967, 50, 245.

Tuesday, 30 July 2013

Study Shows Diets Lacking Omega-3s Lead to Anxiety, Hyperactivity in Teens


Pittsburgh, PA (Scicasts) – Diets lacking omega-3 fatty acids―found in foods like wild fish, eggs, and grass-fed livestock―can have worsened effects over consecutive generations, especially affecting teens, according to a University of Pittsburgh study.

read at
http://scicasts.com/bio/6358-study-shows-diets-lacking-omega-3s-lead-to-anxiety-hyperactivity-in-teens



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Garlic an antifungal, garlic can also support your immune system, reduce cholesterol, and help control blood sugar levels.

garlic

Garlic is a proven antifungal . Research studies have shown that garlic is effective against pathogens like Candida. In addition to its use as an antifungal, garlic can support your immune system, reduce cholesterol, and help control blood sugar levels.
You can start taking garlic supplements once you have finished your cleanse and moved on to the strict anti-Candida diet. As always, it is better to take two or three antifungals at once to prevent the Candida from adapting, so you can use garlic in addition to other natural antifungals.

How does Garlic help with Candida overgrowth?

There is a wide range of scientific literature supporting the use of garlic as an antifungal. Much of this research is focused on Candida and similar pathogenic organisms. For example, a 1988 study (see the full text here) found that “the growth of Candida Albicans was found to be markedly inhibited by AGE [aqueous garlic extract]”. According to another article by Huntington College of Health Sciences, “Research has clearly shown that garlic has anticandidal activity, inhibiting both the growth and function of Candida Albicans”.
One of the key compounds in garlic is ajoene, a proven antifungal that has been shown to be effective against many fungal strains. Ajoene is formed from a compound named allicin and an enzyme named allinase. When these two natural compounds come into contact (by chopping the garlic, crushing it or by other means), they form an antibacterial agent named allicin, which then combines to form ajoene. Although this has proven antifungal properties, the exact mechanism by which this happens is not clear. As with other antifungals, scientists suspect that it works by disrupting the cells walls of the Candida yeast cells.
A major advantage of garlic is that it is so easy to include in your treatment plan. Garlic tablets, softgels and oils are widely available, and fresh garlic cloves make a tasty addition to many recipes. You can use garlic as a complement to your other antifungals without having to spend a great deal of money. To get the best results and prevent the Candida yeast from adapting to the treatment, it is best to take two or three antifungals at the same time.

How do you take Garlic?

Garlic products can be found in a number of different forms, in both your supermarket and your health food store. In your supermarket you will find items like fresh garlic cloves, garlic paste, crushed garlic, garlic flakes or garlic powder. Your health food store should stock garlic tablets and garlic oil.
Each type contains different levels of the active ingredients, so make sure to read the ingredients. Here is a basic run-down of the recommended dosage for each type:
  • Garlic cloves: 2 to 4 grams per day of fresh, minced garlic clove
  • Garlic Tablets: 600 to 900 mg daily, freeze-dried garlic standardized to 1.3% alliin or 0.6% allicin
  • Garlic Oil: 0.03 to 0.12 mL three times a day

Who should not take Garlic?

Although a natural remedy, concentrated garlic can still interact with other medicines, so always consult a health professional. Garlic has a blood-thinning property that can be very useful, but can also be dangerous to sufferers of hemophilia or platelet disorders, as well as pregnant women or patients about to undergo surgery.
Side effects from garlic include upset stomach, bloating, bad breath, body odor, and a stinging sensation on the skin from handling too much fresh or dried garlic. Handling garlic may also cause the appearance of skin lesions.
Other side effects that have been reported by those taking garlic supplements include headache, fatigue, loss of appetite, muscle aches, dizziness described as vertigo (namely, the room spinning), and allergies such as an asthmatic reaction or contact dermatitis (skin rash).
Some people may suffer a mild allergic reaction to concentrated garlic. Others may have an upset stomach, body odor, bad breath, headache, loss of appetite or fatigue. It may prompt a skin reaction, such as a stinging in the hands.