Drug-drug co-crystals.

Figure 1

Representation of drug-drug co-crystal and combination drug.

 

 

 

 

Active pharmaceutical ingredients (APIs) are most conveniently developed and delivered orally as solid dosage forms that contain a defined crystalline form of an API. Co-crystal is a crystalline entity formed by two different or more molecular entities where the intermolecular interactions are weak forces like hydrogen bonding and π-π stacking. Co-crystals are an enabling technology that is used in new or existing drug delivery systems by majority of pharmaceutical companies in formulation and drug development.

 

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http://europepmc.org/articles/PMC3555774

Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?

Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?

B Patwardhan, RA Mashelkar - Drug discovery today, 2009 - Elsevier

Drug discovery strategies based on natural products and traditional medicines are re-
emerging as attractive options. We suggest that drug discovery and development need not
always be confined to new molecular entities. Rationally designed, carefully standardized, ...

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Drug discovery strategies based on natural products and traditional medicines are re-emerging as attractive options. We suggest that drug discovery and development need not always be confined to new molecular entities. Rationally designed, carefully standardized, synergistic traditional herbal formulations and botanical drug products with robust scientific evidence can also be alternatives. A reverse pharmacology approach, inspired by traditional medicine and Ayurveda, can offer a smart strategy for new drug candidates to facilitate discovery process and also for the development of rational synergistic botanical formulations.

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[PDF] from ias.ac.in

>

Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?

http://repository.ias.ac.in/22146/1/342.pdf  pdf for noncommercial use
http://www.sciencedirect.com/science/article/pii/S1359644609001767

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Scientists have identified a new way to stop malaria parasites from multiplying, an important step in developing new treatments for the disease, which killed an estimated 1.2 million people in 2010.
The activity of an enzyme called NMT is essential for the survival and viability of the most common malaria parasite.

This enzyme may be the best way to stop malaria - Futurity

futurity.org

read at

http://www.futurity.org/stop-malaria-target-parasites-weak-spot/?utm_source=rss&utm_medium=rss&utm_campaign=stop-malaria-target-parasites-weak-spot