Sunday 26 October 2014

Application of Continuous Flow Micromixing Reactor Technology for Synthesis of Benzimidazole Drugs

Abstract Image
Synthesis of pharmaceutically active compounds by employing continuous flow micromixing reactor technology is an interesting research area. In this article we describe the synthesis of benzimidazole core drugs, 
such as lansoprazole (1a), pantaprazole (1b), and rabeprazole (1c) by using a continuous flow micromixing reactor technology. A key feature of the sulfoxidation includes the decreasing the reaction time from 3 h to ∼1 s to minimize the formation of sulfone impurities and improve the yields.
http://pubs.acs.org/doi/abs/10.1021/op300325f?journalCode=oprdfk
Center of Excellence in Process Engineering, Research and Development, Integrated Product Development, Dr. Reddy’s Laboratories Ltd., Survey Nos. 42, 45, 46, and 54, Bachupally, Qutubullapur, Ranga Reddy District 500072, Andhra Pradesh, India
Org. Process Res. Dev.201317 (10), pp 1272–1276
DOI: 10.1021/op300325f
http://pubs.acs.org/doi/abs/10.1021/op300325f?journalCode=oprdfk

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