During the process known as metastasis, cancer cells detach from the bulk of the tumor and colonize distant organs. In order to do so, they enter the blood circulation by attaching to the cells that constitute tumor vessels. This event is driven by interactions occurring between Galβ1–3GalNAcα1-Ser/Thr, a disaccharide present on the surface of tumor cells, and galectin-3, a protein situated on vascular cells.
http://www.chemistryviews.org/details/news/4540321/Cancer_Fighting_Fish_Source_of_New_Drugs.html
- Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostatecancer metastasis,
P. Guha, E. Kaptan, G. Bandyopadhyaya, S. Kaczanowska, E. Davila, K. Thompson, S. S. Martin, D. V. Kalvakolanu, G. R. Vasta, H. Ahmed,
Proc. Natl. Acad. Sci. USA 2013.
DOI: 10.1073/PNAS.1202653110
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